The Effect of Disease on Drug Disposition

Kwabena O.M. Adubofour1
1. Centre for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, Accra – Ghana.

Vol.11  No.1-2  January -June 1988, pp 9-14
Published online June, 2022.
© 1988 The Author(s). This is an open access article under the CCBY license


Clinical Pharmacology has been defined as the scientific study of drugs in man and it is in the setting of the disease state that this science must ultimately be applied Techniques for drug assay, tissue response elucidation and the determination of other important pharmacological variables have resulted in better understanding of the mechanisms of action of drugs and the way these agents are handled in the body.

This paper reviews the results of the application of these methods to study the effects of disease on drug disposition. This area of study is an important and ever expanding research interest of Clinical Pharmacologists and Clinical Pharmacists worldwide, The emphasis has been rightly placed since the information that is emerging not only improves prescribing practice but refines the art and science of drug use in therapeutics.

Pathological States

The pathological conditions considered in this review include:

  1. Liver disease
  2. Heart failure
  3. Kidney failure and
  4. Other disease stated affecting gastrointestinal motility.

© The Author(s) 1988. Published by the Pharmaceutical Society of Ghana (PSGH). This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.